Macrophage polarization in response to ECM coated polypropylene mesh

Macrophage Polarization Due to Interleukin-4 Coated Polypropylene Meshes

Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response.

Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These materials provide robust mechanical strength and are quickly incorporated into host tissue; factors that contribute to reduced hernia recurrence rates. However, such mesh devices cause a foreign body response with the associated complications of fibrosis and patient discomfort. In contrast, ...

Polyvinylidene Fluoride-coated Polypropylene Mesh for Intraperitoneal Onlay Mesh (IPOM) Repair of Ventral and Incisional Herniae

Background: Dynamesh is a Polyvinylidene fluoride-coated polypropylene mesh. Its main use is for ventral hernia repairs as an on-lay mesh. The mesh was designed to have similar elasticity to the abdominal wall. It is reported to have good anti-adhesive properties while the large pores ensure rapid integration into the abdominal wall. A small series last year reported a high rate of complication...

MicroRNAs in immune response and macrophage polarization.

Inflammation is essential to combat invading microbial pathogens. In this process, the involvement of multiple immune cell populations is crucial in mounting an optimum immune response. In the past decade, a new class of noncoding small RNAs, called microRNAs (miRNAs), has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response i...

Efficacy of Polypropylene Mesh Coated with Bioresorbable Membrane (Sepramesh) for the Repair of Abdominal Wall Defects in Horses

Objective: The aim of this study was to compare the use of Polypropylene mesh (Prolene) and Sepramesh, a coated Polypropylene mesh with a protective layer of Seprafilm on its visceral side, for the repair of abdominal wall defects in horses. We also aimed to quantify the consequent visceral adhesion and tissue inflammatio Design: Experimental study. Animals: Ten horses. Methods: The horses w...